Huxley as a Mutationist

Andrew Fielding Huxley (19172012)

Andrew Fielding Huxley, OM 1983; Kt 1974; FRS 1955; PRS 1980–1985, MA, Hon. ScD Cantab. Physiologist and Biophysicist. Born Hampstead, London, 22 November 1917. Demonstrator, 1946–50, Assistant Director of Research, 1951–59, and Reader in Experimental Biophysics, 1959–60, Physiological Laboratory, Cambridge; Director of Studies, Trinity College, Cambridge, 1952–60; Jodrell Professor 1960–69, Ro...

Hodgkin Huxley Equations

We will see the Hodgkin Huxley equations the experiments as sumptions and analysis De nitions Remember Cable Theory The ecuation for the PASIVE cable are As we know the axon is not passive It has active conductances Let s change the circuit Vout

The Huxley Lecture

A Hodgkin-Huxley model exhibiting bursting oscillations.

We investigate bursting behaviour generated in an electrophysiological model of pituitary corticotrophs. The active and silent phases of this mode of bursting are generated by moving between two stable oscillatory solutions. The bursting is indirectly driven by slow modulation of the endoplasmic reticulum Ca2+ concentration. The model exhibits different modes of bursting, and we investigate mod...

A Blueprint for a Mutationist Theory of Replicative Strand Asymmetries Formation

In the present review, we summarized current knowledge on replicative strand asymmetries in prokaryotic genomes. A cornerstone for the creation of a theory of their formation has been overviewed. According to our recent works, the probability of nonsense mutation caused by replication-associated mutational pressure is higher for genes from lagging strands than for genes from leading strands of ...